Notice NOT-GM-19-022 from the NIH Guide for Grants and Contracts

Funding Opportunity PA-19-187 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) awards senior individual research training fellowships to experienced scientists who wish to make major changes in the direction of their research careers or who wish to broaden their scientific background by acquiring new research capabilities as independent investigators in research fields relevant to the missions of participating NIH Institutes and Centers. This Funding Opportunity Announcement (FOA) does not allow applicants to propose to lead an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial, but does allow applicants to propose research experience in a clinical trial led by a sponsor or co-sponsor.

Notice NOT-AR-19-036 from the NIH Guide for Grants and Contracts

Notice NOT-AT-19-022 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-CA-19-044 from the NIH Guide for Grants and Contracts. This FOA will invite U01 applications in the specific area of cancer immunotherapy-related adverse events. Investigators are encouraged to submit applications that focus on mechanisms of immune reactivity/tolerance and/or autoimmune pathways that could be applied to improving immunotherapeutic approaches while simultaneously eliminating or reducing the severity of inflammatory or autoimmune responses. A related area of interest is studies designed to enhance the target specificity of immunotherapeutic reagents, to reduce or prevent irAEs. An additional synergistic focus of interest is the identification of predictive biomarkers of cancer patients at risk for developing irAEs. Understanding risk factors for developing an irAE would better inform patient stratification at the start of therapy and influence clinical monitoring. Achieving the goals of the RFA should establish a deeper understanding of the origins and activation pathways leading to inflammatory or autoimmune adverse events that currently limit the use of various immunotherapy regimens in patients.

Funding Opportunity RFA-FD-19-004 from the NIH Guide for Grants and Contracts. The objective of this FOA is the development, implementation, and management of a funding system in which State, Tribal, and Territorial Grade A Milk Safety and National Shellfish Sanitation regulatory programs can apply and be subawarded funds to support technical training and equipment purchases, and to improve the implementation of the Grade "A" Milk Safety Program and the National Shellfish Sanitation Program (NSSP). Funds may be awarded to up to two non-profit association/organization(s), upon which they will subsequently administer and subaward funds to State, Tribal, and Territorial regulatory agencies for facilitating improvements to and advancing the Grade A Milk Safety Program and the National Shellfish Sanitation Program.

Notice NOT-CA-19-026 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-FD-19-006 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for UG3/UH3 cooperative agreements to support the development of a publicly available core set(s) of COAs and their related endpoints for specific disease indications. The UG3/UH3 Phase Innovation Award Cooperative Agreement involves 2 phases. The UG3 phase will provide funding for 1 to 2 years to conduct planning activities. The UH3 phase will provide funding for 3 to 4 years to projects that successfully complete the planning activities and reach the projected milestones set in the UG3 phase. UH3 phase awards will be awarded after administrative review of eligible UG3 phase awards that have met the scientific milestone and feasibility requirements necessary for UH3 phase implementation. The number of awards is dependent on the availability of funds. The UG3/UH3 application must be submitted as a single application, and applicants should note specific instructions for each phase in this FOA. The total award project period will not exceed 5 years.

Notice NOT-EB-19-003 from the NIH Guide for Grants and Contracts

Notice NOT-HL-19-682 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-079 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-19-012 from the NIH Guide for Grants and Contracts. The National Institute of Neurological Disorders and Stroke (NINDS) and National Institute on Aging (NIA) intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for a large prospective clinical research study to determine the specific subsets of stroke events that predict cognitive impairment and dementia in post-stroke populations in the United States, including in health disparities populations, and what additional clinical factors and comorbidities along the AD/ADRD spectrum may causally synergize with stroke to result in (or prevent) cognitive impairment and dementia outcomes. The goals of this initiative are to determine the association between specific subsets of stroke events and subsequent cognitive impairment and dementia in post-stroke populations in the United States, including in health disparities populations; to identify additional clinical factors and comorbidities that may affect these associations; and to contribute to development and validation of clinical-trial ready diagnostic and progression biomarkers for post-stroke dementia. It is expected that the study design will also allow for determination of interrelationships (cross-sectional and longitudinal) among the stroke event, overall cerebrovascular and cardiovascular disease and risk factors (including sex, racial, and ethnic differences), dementia-relevant genetic variants (including ApoE) and mutations (e.g. in Notch 3) previously associated with Alzheimer's disease (e.g. APP, PS1, PS2, PICALM, CLU, TREM2), cognitive trajectories including decline and resistance to decline, as well as amyloid and tau biomarkers of Alzheimers pathology during life.

Notice NOT-OD-19-083 from the NIH Guide for Grants and Contracts

Notice NOT-ES-19-008 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-080 from the NIH Guide for Grants and Contracts

Notice NOT-NS-19-036 from the NIH Guide for Grants and Contracts

Notice NOT-MD-19-021 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-073 from the NIH Guide for Grants and Contracts

Notice NOT-ES-19-007 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-074 from the NIH Guide for Grants and Contracts