Notice NOT-HL-19-676 from the NIH Guide for Grants and Contracts

Notice NOT-AR-19-035 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-FD-19-011 from the NIH Guide for Grants and Contracts. The purpose of this program is to support research activities that expand the knowledge base related to complex products and formulation development, analysis, and manufacturing control to advance risk-based quality assessment of new and generic drug products. We will also consider biological products relevant to CDER (e.g., monoclonal antibodies and therapeutic proteins) for this announcement.

Notice NOT-FD-19-006 from the NIH Guide for Grants and Contracts

Notice NOT-HL-19-683 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-077 from the NIH Guide for Grants and Contracts

Notice NOT-PM-19-003 from the NIH Guide for Grants and Contracts

Notice NOT-PM-19-002 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-FD-19-003 from the NIH Guide for Grants and Contracts. The Food and Drug Administration (FDA)/ Center for Food and Safety and Applied Nutrition (CFSAN) is announcing its intention to receive and consider a single source application for the award of a cooperative agreement in fiscal year 2019 to the Illinois Institute of Technology to support the Institute for Food Safety and Health (IFSH). The purposes of this continued support are to: 1. Carry out multidisciplinary applied research projects on the safety of processed foods; on food processing and packaging technologies; on the impact of these processing strategies on the nutritional quality of food; and on laboratory method performance (including method validation) that address issues associated with FDA-regulated products and that are consistent with CFSAN's Science and Research Strategic Plan; 2. Maintain and facilitate the further development of the IFSH collaborative research program by leveraging resources among U.S. government agencies, universities (including other IIT components), and the food industry to achieve practical solutions to food safety and food processing issues; 3. Develop and implement outreach and communication programs with stakeholders to identify research needs and to facilitate the use of the information produced by the research program; and 4. Support the implementation of the FDA Food Safety Modernization Act through research, education, and outreach, with particular emphasis on the science behind preventive controls associated with manufacturing, processing, packing and holding of food.

Funding Opportunity PAR-19-185 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NHGRI R25 program is to support educational activities that support advanced level courses that are intended to disseminate new knowledge, techniques, methods, and analyses related to the mission of the NHGRI. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development.

Notice NOT-CD-19-001 from the NIH Guide for Grants and Contracts

Notice NOT-AA-19-010 from the NIH Guide for Grants and Contracts

Notice NOT-AG-19-005 from the NIH Guide for Grants and Contracts

Notice NOT-AG-19-004 from the NIH Guide for Grants and Contracts

Notice NOT-GM-19-014 from the NIH Guide for Grants and Contracts

Notice NOT-AT-19-023 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-070 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-ES-19-001 from the NIH Guide for Grants and Contracts. Chemical modifications of protein, DNA and RNA nucleoside moieties play critical roles in regulating gene expression. Emerging evidence suggests RNA modifications have substantive roles in multiple basic biological processes. Epitranscriptomics can be defined as the aggregate suite of functional biochemical modifications to the transcriptome within a cell. Recent studies in yeast, Drosophila, rodent and human models demonstrate that stressors can induce RNA modifications, with specific reprogramming of some regulatory RNAs. The NIEHS seeks to solicit innovative, mechanistic research applications that are focused on how environmental exposures are associated and involved with the functional activities of RNA modifications and pathways that may be modified or misregulated, associated with adverse health outcomes and/or be useful as biomarkers of exposure and/or exposure-induced pathologies. The study of functional chemical RNA modification has identified important emerging roles in cellular regulation and gene expression. However, the impact of environmental exposures on functional RNA modifications has been relatively understudied and may present a new mechanism for enhanced understanding the relationships between exposures and the development of complex human diseases. The NIEHS will use the R01 mechanism to support hypothesis driven research using approaches that incorporate principles of toxicology with RNA modification biological and/or chemical expertise and utilizes state of the art technologies.

Funding Opportunity RFA-ES-19-002 from the NIH Guide for Grants and Contracts. Chemical modifications of proteins, DNA and RNA nucleoside moieties play critical roles in regulating gene expression. Emerging evidence suggests these RNA modifications (epitranscriptomics) have substantive roles in basic biological processes. Recent studies in yeast, Drosophila and rodent models demonstrate stressors can induce RNA modifications, with specific epitranscriptomic reprogramming of some regulatory RNAs. The purpose of the eFRAMED FOA is to solicit and support R21 applications that propose conducting innovative, high risk, high reward research to enhance our understanding of how environmental exposures impact this layer of cellular regulation.

Notice NOT-GM-19-011 from the NIH Guide for Grants and Contracts