Funding Opportunity RFA-AG-24-037 from the NIH Guide for Grants and Contracts. The purpose of this limited competition Request for Applications (RFA) is to continue data collection, development, and dissemination of the National Health and Aging Trends Study (NHATS) and National Study of Caregiving (NSOC). Continuation of the study requires both knowledge of, and access to, the NHATS and NSOC sample frames. Therefore, this RFA is limited to investigators and institutions with access to the NHATS and NSOC sample frame, as the frame will be used to contact and collect new data from participants. This RFA aims to provide additional research opportunities to use NHATS to formally study disability and Alzheimers disease (AD) and AD-related dementias (ADRD). This single integrated award combining NHATS and NSOC seeks to implement the comments of the NHATS Data Monitoring Committee to include continued the core elements of NHATS/NSOC and expand content to include enhanced cognitive/dementia measures, new sensory measures, richer dementia care measures, life course measures to capture sources of health disparities, improved residential care data, and an expanded accelerometry sample to facilitate AD/ADRD research that could enhance research targeting related NIA Dementia Care Milestones. Applicants are required to submit a Letter of Support from their institution confirming that they have access to personally identifiable information about NHATS and NSOC panel members and the ability to contact study participants for longitudinal follow-up and administrative/program data linkage.

Notice NOT-AT-24-008 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AT-24-003 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) intends to support the development of innovative methods for quantitative evaluation of myofascial tissues for pain management involving research participants using a two-phase grant funding mechanism. This effort is part of the NIH HEALSM (Helping to End Addiction Long-term) Initiative to speed the development and implementation of scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative is bolstering research across NIH to (1) improve treatment and prevention of opioid misuse and opioid use disorder and (2) enhance pain management. This notice of funding opportunity (NOFO) seeks research applications to develop quantitative measures of myofascial tissues and assess their abilities to detect changes to myofascial tissues across a variety of pain management interventions. Candidate objective measures may be based on minimally invasive imaging technologies, electrophysiological recordings, integration of multiparametric imaging and electrophysiology approaches, or their integration with other markers (e.g., immune factors, genomic markers, physiological factors) through multiscale modeling or machine learning analysis. The first phase, funded by the R61, will provide funding for up to 3 years to develop quantitative measures that can differentiate abnormal myofascial tissue from healthy tissues using cross-sectional correlations with clinical signs/symptoms. In addition, the R61 phase should include planning activities for the R33 phase. The second phase, funded under the R33, will provide support to assess the abilities of the quantitative measures developed in the R61 phase to measure tissue changes in response to therapies or manipulations that may relieve pain using rigorous, longitudinal clinical study design. The combined R61/R33 should not exceed 5 years. Transition from the R61 to the R33 phase of the award will be administratively reviewed and will be determined based on successful co

Funding Opportunity RFA-AG-24-026 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites R34 applications to support the planning activities necessary to develop social network interventions to promote health across the lifespan, especially in populations in which they are currently largely underdeveloped and untested (such as populations in mid- and late-life). Applications suited to this R34 will focus on planning activities for social network interventions for which a target interpersonal process of behavior change or social network characteristic has already been identified. Planning activities are those activities that are expected to yield necessary and sufficient information to inform final decisions about a social network health behavior change intervention prior to instigation of a hypothesis-driven trial to test a social network intervention. Activities may include (but are not limited to) team-building, protocol development, piloting of systems for data collection and/or management, feasibility and acceptability testing, staff training, and establishing documentation procedures. Basic experimental and observational behavioral and/or social science applications that test how intrapersonal and interpersonal mechanisms of behavior change interact with, influence, or are influenced by characteristics of social networks are outside the scope of this RFA. Research to identify targets for future social network health behavior change interventions and/or to develop, refine, or optimize measures (assays) of putative targets are also outside the scope of this RFA. Both of these types of research are most appropriate for the companion R01 RFA (RFA-AG-24-025). Projects that propose to test the efficacy or effectiveness of a social network health behavior change intervention are also outside the scope of this RFA, which focuses only on pre-trial planning and development activities.

Funding Opportunity RFA-AG-24-025 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to invite basic observational or experimental behavioral and/or social science R01 applications that test how intrapersonal and interpersonal mechanisms of behavior change interact with, influence, or are influenced by characteristics of social networks, with implications for health. Research supported through this NOFO will examine at least two levels of analysis: interpersonal processes and social network characteristics. Projects will identify targets for future social network health behavior change interventions across the lifespan, especially in populations in which they are currently largely underdeveloped and untested (such as populations in mid- to- late life). Basic research to develop, refine, or optimize measures (assays) of putative targets (e.g., intra/interpersonal mechanisms of behavior change and/or social network characteristics) are also supported by this NOFO. Clinical trials that do not meet the federal definition of basic research (CFR 272.3) are not responsive to this RFA. Projects that propose to support the planning activities necessary to develop social network interventions for which a target has already been identified are most appropriate for the R34 RFA companion (RFA-AG-24-026).

Notice NOT-NS-23-071 from the NIH Guide for Grants and Contracts

Notice NOT-TR-23-021 from the NIH Guide for Grants and Contracts

Notice NOT-CA-23-070 from the NIH Guide for Grants and Contracts

Notice NOT-TR-23-020 from the NIH Guide for Grants and Contracts

Notice NOT-HL-23-089 from the NIH Guide for Grants and Contracts

Notice NOT-RM-23-014 from the NIH Guide for Grants and Contracts

Notice NOT-RM-23-015 from the NIH Guide for Grants and Contracts

Notice NOT-RM-23-016 from the NIH Guide for Grants and Contracts

Notice NOT-RM-23-017 from the NIH Guide for Grants and Contracts

Notice NOT-DK-23-029 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-23-008 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement will provide support for a Human Islet Research Enhancement Center that will supply the infrastructure needed to support research coordination, collaboration and dissemination of advances made by the NIDDK funded Human Islet Research Network (HIRN).

Funding Opportunity PAR-23-199 from the NIH Guide for Grants and Contracts. NIH established a clinical genomics infrastructure to develop an openly accessible knowledgebase that promotes data sharing and provides standardized infrastructure and tools for determining the clinical relevance of genetic variants through two initiatives: the Clinical Genomics Resource (ClinGen) and the Clinical Variant Database (ClinVar) of clinical variation. ClinGen defines the clinical relevance of genes and variants for use in precision medicine and research by standardizing clinical annotation and interpretation of variants and implementing evidence-based expert consensus assertions. The purpose of this Notice of Funding Opportunity (NOFO) is to establish Expert Panels that will select genes and genomic variants associated with diseases or conditions of high priority to participating NIH Institutes and Centers (ICs) and systematically determine their clinical significance for diagnosis and treatment of these diseases or conditions. The Genomic Curation Expert Panels funded through this NOFO are required to utilize the NHGRI Clinical Genomics Resource (ClinGen) and the NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure.

Notice NOT-HD-23-017 from the NIH Guide for Grants and Contracts

Notice NOT-NS-23-070 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-214 from the NIH Guide for Grants and Contracts. "This FOA will solicit R01 applications that propose studies in animal, cell culture, and/or human tissue models to elucidate the mechanisms by which COVID-19 interacts with and/or modulates AD/ADRD-relevant phenotypes. Either the model itself or the experimental readouts will be required to incorporate AD/ADRD risk factors, pathologies, or relevant comorbidities. To this end, proposals can focus on one or more of the following: - Mechanistic studies that address how COVID-19 impacts CNS pathology and cognitive outcomes when AD/ADRD pathology is already present (for example, in a model of AD/ADRD). - Mechanistic studies that address how COVID-19 accelerates AD/ADRD pathology and cognitive deficits in a prodromal model (early phase, pre-symptomatic). - Mechanistic studies that address how COVID-19 predisposes for AD/ADRD and/or interacts with relevant comorbid conditions and risk factors (cellular mechanisms that could potentially increase the risk for future AD/ADRD)."